• Recently multiple receptor agonists have been developed to t

  2021-12-03

  

  Recently, multiple receptor agonists have been developed to treat type II diabetes (Finan et al., 2013, Finan et al., 2015). We have tested novel dual GLP-1/GIP receptor agonists that showed good neuroprotective effects that are superior to single GLP-1 analogues (Cao et al., 2016, Jalewa et al., 20

• Cx mimetic peptides short synthetic peptides corresponding t

  2021-12-03

  

  Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino BQ-788 sodium salt sale sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel functio

• Iodination of commercially available with excess ICl in AcOH

  2021-12-03

  

  Iodination of commercially available with excess ICl in AcOH gave a quantitative yield of , which was cyclized with benzyl thioamides to give the 2-benzyl-9,10-dihydro-4-1-thia-3,4-diaza-benzo[]azulenes . Coupling of the iodides with heterocycles including imidazoles, triazoles, or zinc cyanide us

• Most studies to date have focused

  2021-12-03

  

  Most studies to date have focused on the physiological functions of FPS in plants. As mentioned above, numerous factors affect FPS expression and FPS function. However, FPS enzymatic assays require radiolabeled substrate and thus detailed enzymatic characterizations of FPS, including substrate speci

• Hyperactivation of Notch pathway can give rise to transforma

  2021-12-03

  

  Hyperactivation of Notch1 pathway can give rise to transformation into T-ALL in murine models. In more than 50% of acute T-cell lymphoblastic leukemias oncogenic activating mutations of Notch1 have been detected and inactivation of Notch1 signaling impairs leukemia cell proliferation and promotes ap

• DBIBB receptor br Introduction Ovarian cancer patients have

  2021-12-03

  

  Introduction Ovarian cancer patients have the highest mortality rate amongst patients with gynecologic cancers. The 10-year survival rate of ovarian cancer patients is cancer DBIBB receptor with BRCA1/2 mutation [2]. Several studies have indicated the role of dysregulation of histone methylation

• br Hippo Signaling in Autoimmunity An

  2021-12-03

  

  Hippo Signaling in Autoimmunity An imbalance of T cell subsets, such as immunosuppressive regulatory T JW 55 (Treg) and inflammatory TH17, has a key role in autoimmune diseases. Recently, investigations found that TAZ but not YAP enhances TH17 differentiation but attenuates Treg differentiation

• Oltipraz has been shown to inhibit the growth

  2021-12-03

  

  Oltipraz has been shown to inhibit the growth of HCC Meropenem and is being evaluated in clinical trials as a potential anti-cancer drug for HCC (Mann et al., 2009; Piton et al., 2005; Yates and Kensler, 2007). The present observation that pre-treatment of tumorigenic liver cells with oltipraz cause

• Other N substituted carboxamide oxy

  2021-12-03

  

  Other N-substituted-6-carboxamide-3-oxy-pyridine derivatives 52a, 52h, 52i, and 53h were synthesized using an alternative route. The Pd-catalyzed Heck aminocarbonylation of 44 or 45 with (PPh3)2PdCl2 catalyst in the presence of Et3N under CO atmosphere successfully provided various N-substituted-6-c

• One important aspect about GSK inhibitors is their effect

  2021-12-03

  

  One important aspect about GSK-3 inhibitors is their effect on pluripotency of Protease Inhibitor Library [4]. Many GSK-3 inhibitors are ATP-competitive and suppress both GSK-3alpha and GSK-3beta [476]. BIO was shown to suppress GSK-3 activity and promote Wnt/beta-catenin signaling. This combinatio

• In conclusion we have identified ten novel GPCR genes

  2021-12-03

  

  In conclusion, we have identified ten novel GPCR genes and a pseudogene. Transcripts for GPR78, GPR81, GPR94, GPR95, GPR101, GPR103 and P2Y were detected in various CNS and peripheral tissues. Given the high levels of identity observed within paralogous oGPCR gene clusters, future efforts will likel

• br Acknowledgements This work was supported by grants from

  2021-12-02

  

  Acknowledgements This work was supported by grants from la Ligue Nationale Française Contre le Cancer « Equipe LNCC 2016 » and Electricité de France RB 2016-17 (to M.S.), NU ORAU (http://www.nu.edu.kz) and Ministry of Education and Science of the Republic of Kazakhstan, program 0115RK03029 (to B.

• Enzyme linked immunosorbent assay ELISA is a

  2021-12-02

  

  Enzyme-linked immunosorbent assay (ELISA) is a rapid and simple test widely used for the detection of humoral immune responses following infection/vaccination. However, commercially available ILTV ELISA use the whole virus as the detecting antigen and therefore may not be sensitive for the detection

• br Transporter based brain targeting nano DDS Drug

  2021-12-02

  

  Transporter-based brain-targeting nano-DDS Drug delivery to the central nervous system (CNS) is still challenging due to the bloodbrain barrier (BBB)53., 54.. The BBB is a natural defense barrier protecting the bms-536924 from harmful substances. Since only selected, neutral, lipophilic small mo

• br Acknowledgements br Introduction Benzodiazepine BZ treatm

  2021-12-02

  

  Acknowledgements Introduction Benzodiazepine (BZ) treatment is widely used for quick and efficient anxiolytic and sedative responses. However, when the use is extended to longer periods, adverse effects emerge. These include tolerance to the initial drug effect, dependence as revealed by withd

16779 records 564/1119 page Previous Next First page 上5页 561562563564565 下5页 Last page