• We have shown that the glycation of collagen

  2020-07-30

  

  We have shown that the glycation of collagen hinders collagen-DDR2 binding. McCarthy et al. previously showed reduced binding of rat osteosarcoma-derived cells (UMR106) to glycated collagen. The authors speculated that glycation of collagen attenuates collagen binding to collagen-specific integrins

• Next we tried to specifically inhibit DDR

  2020-07-30

  

  Next, we tried to specifically inhibit DDR2 function in endochondral proliferation and ossification in vivo. We used competitive inhibition with KD-Ddr2 overexpression specifically in cartilage cells, because it is generally difficult to regulate genes by miRNA in vivo. We constructed a transgenic v

• phosphodiesterase inhibitors br Conclusion Several classes o

  2020-07-30

  

  Conclusion Several phosphodiesterase inhibitors of models have successively emerged since the 1970s. Three main models describing Ca2+ binding to CaM are now surviving: All three models explain most of the experimental results obtained up to now. However, the two first ones, due to the symmetri

• Phylogenetic analysis indicates that in poikilothermic verte

  2020-07-30

  

  Phylogenetic analysis indicates that in poikilothermic vertebrates CXCR3a and CXCR3b have evolved independently from a common gene possibly after the 2nd round whole genome duplication but before the split of bony fish and tetrapods (Fig. 1 and Supplementary file 3). Owing to the extra round of whol

• To assess the involvement of the hydrocarbon

  2020-07-30

  

  To assess the involvement of the hydrocarbon chain of C75-CoA positioning in the acyl group binding pocket, we carried out C75-CoA inhibitory experiments with the new mutated protein, CrAT D356A/M564G. This protein has a deep acridine orange pocket for the binding of long-chain instead of short-chai

• br Materials and methods br

  2020-07-30

  

  Materials and methods Results Discussion In our tissue array, we demonstrated that 14-3-3 tau mRNA and protein expression levels decreased in the preeclamptic placentas. 14-3-3 proteins are considered to be important in the functional regulation of trophoblasts and maybe associated with adv

• br Conflicts of interest br

  2020-07-29

  

  Conflicts of interest Acknowledgments National Natural Science Foundation of China (81473014); Top Young Talents of Guangdong Hundreds of Millions of Projects (87316004); Jinan University High-level University Construction Public Health and Preventive Medicine Fund (JNUPHPM2016003) Introduc

• It is known that IgA

  2020-07-29

  

  It is known that IgA is produced and released in the human small intestine in response to Giardia infections [37] and patients with immunoglobulin deficiencies can develop chronic giardiasis [38]. Anti-Giardia IgA was also detected in human saliva and breast milk and associated with protection again

• 1347 br Materials and methods br Results br Discussion

  2020-07-29

  

  Materials and methods Results Discussion The pathophysiology of sepsis is complex, which is a host\'s exaggerated immune response to severe infection increases mortality [13]. During the early phase, sepsis patients present with an exaggerated immune response, also described as a “cytokine

• After calculating all of the

  2020-07-29

  

  After calculating all of the required parameters for vapor-liquid equilibrium modeling, the solubility of SO2 was calculated in all of the investigated DESs. In order to have an evaluation of the two models of NRTL-CPA and UNIQUAC-CPA, the statistical error parameter of AARD% is defined as Eq. (42).

• Furthermore quantitative analysis of localization of CLIC

  2020-07-29

  

  Furthermore, quantitative analysis of localization of CLIC1, CLIC4, and CLIC5 to the mitochondria in isolated adult cardiomyocytes (Fig. 3) revealed similar distribution of CLICs as observed in neonatal cardiomyocytes (Fig. 2). However, CLIC4 and CLIC5 showed a higher degree of colocalization to the

• In addition to the receptor TGF also regulates the DDR

  2020-07-28

  

  In addition to the receptor, TGF-β1 also regulates the DDR1 ligand meaning the type I collagen and the enzyme involved in its maturation (LOXL2). We previously demonstrated that an increase of type I collagen concentration is associated with the presence of more linear invadosomes in U-104 (Juin et

• The presence of H PPases in parasitic

  2020-07-28

  

  The presence of H+-PPases in parasitic protists raises the question of the physiological role of these proteins. So far, they had been extensively characterized mainly in higher plants, and some prokaryotes [1], [2], [3], [4], [5], [6], [7], [16], [20]. A common feature to all these organisms is tha

• br Conflict of interest statement br Renal cell carcinoma is

  2020-07-28

  

  Conflict of interest statement Renal cell carcinoma is the third most common urogenital tumor disease with an estimated incidence of 51,000 cases per year in the United States. Although RCC appears to be curable at nonadvanced stage, locally advanced or lymph node positive tumors are likely to

• Several limitations should be considered in the present stud

  2020-07-28

  

  Several limitations should be considered in the present study. First, compared with prospective study, our cross-sectional research was not powerful enough to establish the causal relationship between the CDKL2 hypermethylation and HCC progression. Second, plasma samples and early HCC patients were

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